Outcomes of Cassia Fistula Bark Hexane Extract on Serum Insulin and Glucose Levels in Diabetic Rats

Background: Cassia fistula (amaltas) is commonly found in Pakistan and frequently used medicines. Its leaves, bark pods are conventionally for the treatment of skin disorders, bacterial infection, constipation, colic, cirrhosis, urinary dysentery, leprosy, rheumatic conditions, jaundice, syphilis, heart diseases diabetes mellitus (DM). Aim: To determine compare outcomes cassia (hexane extract) on serum insulin blood glucose measures high-fat diet-fed (HFD) Streptozotocin-induced type 2 diabetic albino male rats.” Study design: Randomized control trial. Duration setting: Services Institute Medical Sciences (SIMS), Lahore from August 2016 to January 2017. Methods: The research was carried out ninety rats. Rats were induced with by giving high fat diet weeks fourteenth day, single injection low dose streptozotocin (25mg/kg). rats categorized randomly into two groups, randomly, 45 animals each. Group 1 (n=45) group experimental given hexane extract (0.45g/kg) 1ml 0.3 % Carboximethyl cellulose solution using intra gastric tube once a day month. On 31st 4-5 ml cardiac sample collected. Biochemical parameters evaluated. Results: treated bark, exhibited significant (p=0.05) decrease levels. Conclusion: Hexane possesses potent hypoglycemic effects. Keywords: fistula, Hypoglycemic effects, rat